Schuler Vertical Tissue Bath System

The Schuler tissue bath system is our most advanced and feature rich tissue bath system used for the study of force or displacement from a wide variety of tissue preparations such as: atria, papillary muscle (without potential recording), and skeletal and smooth muscle (intestine, bladder, uterus). Isolated intact blood vessels and nerve-muscle preparation experiments are also possible but require the use of special holders. 

To ensure that your system is properly configured as a functional unit that meets your application needs, please complete our Checklist and then contact Technical Services at 800-547-6766 or via email at support@hbiosci.com before placing an order. In Europe, please call +49 7665 92000 or via email at sales@hugo-sachs.de.

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DETAILS

The Schuler tissue bath system is our most advanced and feature-rich tissue bath system used for the study of force or displacement from a wide variety of tissue preparations such as: atria, papillary muscle (without potential recording), and skeletal and smooth muscle (intestine, bladder, uterus). Isolated intact blood vessels and nerve-muscle preparation experiments are also possible but require the use of special holders.

Features & Benefits
Applications
Design
Set Up & Operations
System Components
Additional Equipment Required

Features & Benefits

• Single or 4-channel tissue bath 
• 5, 10, 20 and 50 ml tissue vessels available 
• Multiple choice of tissue holder to adapt to any application 
• Software for data acquisition and control
• Two flush modes: overflow and drain/refill
• Software for data acquisition
• Wide range of force or displacement transducers available

Applications

• Smooth muscles 
• Heart muscles 
• Skeletal muscles 
• Rings, strips 

Design

The rigid construction and ergonomic design of the Schuler Bath allows for rapid tissue mounting and adjustment to minimize tissue drying and hypoxia.Tissue bath volumes of 5, 10, 20 and 50 ml are available along with bath and tissue specific holders. Tissue supports are available for rings, strips andspecialty applications, with or without platinum plate field stimulation electrodes. All tissue holders include an integrated oxygenating frit at the back of the holder to minimize disruption of force and displacement due to bath oxygenation.  A selection of force and displacement transducers is available which are mounted to Vernier positioners. The Vernier micropositioner permits precise adjustment of the preload (pre-stretch) on force transducers,or setting a suitable zero within the range of the displacement transducer.

Please contact technical support for assistance in chosing an appropriate bath and holder for your application.

Set Up & Operation

Positioning of the tissue is greatly simplified by the integrated platform carrying the tissue holder, the micropositioner and the transducer; the platform can be raised so that the tissue holder comes out of the glass vessel to provide ready access to the tissue. The flushing solution is warmed by flow-through heat exchangers mounted on the Plexiglas Base. A central connection for gas addition is provided. Six needle valves provide individual adjustment of the gas flow to the four tissue vessels as well as the handy preparation dish and the solution reservoir.

Electrical Stimulation of isolated tissue requires the use of tissue holders with stimulation electrodes of the appropriate volume and a suitable stimulator which has a separate output for each tissue and also produces stimulus trains for stimulating smooth muscle. The amplitude on each stimulus output should be individually adjustable for each tissue.

System Components

Systems are available as individual components or complete turn-key solutions. Accessories include, tissue preparation dishes, buffer reservoirs, wide range of tissue supports, transducers (force and displacement) amplifiers, multi-channel stand alone or programmable stimulators, thermocirculator and all required tubing and connectors.

Additional Equipment Required

Thermociculator, a reservoir for the solution,transducers, monitoring system setup using the PLUGSYS Amplifier System. The HSE-DAQ Software Package ACAD, is used to record and export force and displacement measurements. Optional software and hardware modules are available for computer-controlled field stimulation, tissue pretension using electronically controlled Vernier positioners and tissue bath flushing. In case of electrical stimulation a multiple output stimulator is required.